Calendario completo del Deportivo en Primera RFEF
| Jornada | Fecha | Partido |
|---|---|---|
| 1 | 29/08/2021 | Deportivo vs Celta B |
| 2 | 05/09/2021 | Tudelano vs Deportivo |
| 3 | 12/09/2021 | Calahorra vs Deportivo |
| 4 | 19/09/2021 | Deportivo vs Badajoz |
| 5 | 26/09/2021 | Unionistas vs Deportivo |
| 6 | 03/10/2021 | Deportivo vs Logroñés |
| 7 | 10/10/2021 | Real Unión vs Deportivo |
| 8 | 17/10/2021 | Deportivo vs Sanse |
| 9 | 24/10/2021 | Racing de Santander vs Deportivo |
| 10 | 31/10/2021 | Deportivo vs Zamora |
| 11 | 07/11/2021 | Logroñés vs Deportivo |
| 12 | 14/11/2021 | Deportivo vs Extremadura |
| 13 | 21/11/2021 | Rayo Majadahonda vs Deportivo |
| 14 | 28/11/2021 | Deportivo vs Athletic B |
| 15 | 05/12/2021 | Racing de Ferrol vs Deportivo |
| 16 | 12/12/2021 | Deportivo vs Valladolid Promesas |
| 17 | 19/12/2021 | Cultural Leonesa vs Deportivo |
| 18 | 09/01/2022 | Deportivo vs Talavera |
| 19 | 23/01/2022 | Dux vs Deportivo |
| 20 | 26/01/2022 | Zamora vs Deportivo |
| 21 | 30/01/2022 | Deportivo vs Racing de Santander |
| 22 | 06/02/2022 | Deportivo vs Real Unión |
| 23 | 13/02/2022 | Logroñés vs Deportivo |
| 24 | 20/02/2022 | Deportivo vs Calahorra |
| 25 | 27/02/2022 | Sanse vs Deportivo |
| 26 | 06/03/2022 | Deportivo vs Racing de Ferrol |
| 27 | 13/03/2022 | Badajoz vs Deportivo |
| 28 | 20/03/2022 | Deportivo vs Cultural |
| 29 | 27/03/2022 | Celta B vs Deportivo |
| 30 | 03/04/2022 | Deportivo vs Rayo Majadahonda |
| 31 | 10/04/2022 | Athletic B vs Deportivo |
| 32 | 17/04/2022 | Deportivo vs Dux |
| 33 | 24/04/2022 | Talavera vs Deportivo |
| 34 | 01/05/2022 | Deportivo vs Logroñés |
| 35 | 08/05/2022 | Extremadura vs Deportivo |
| 36 | 15/05/2022 | Deportivo vs Tudelano |
| 37 | 22/05/2022 | Valladolid Promesas vs Deportivo |
| 38 | 29/05/2022 | Deportivo vs Unionistas |